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KMID : 0191120130280010120
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Journal of Korean Medical Science
2013 Volume.28 No. 1 p.120 ~ p.127
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Risk Factors for Neurologic Complications of Hand, Foot and Mouth Disease in the Republic of Korea, 2009
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Kim Seong-Joon
Kim Jong-Hyun
Kang Jin-Han
Kim Dong-Soo
Kim Ki-Hwan
Kim Kyung-Hyo
Kim Young-Hoon
Chung Ju-Young
Bin Joong-Hyun
Jung Da-Eun
Kim Ji-Hong
Kim Hwang-Min
Cheon Doo-Sung
Kang Byung-Hak
Seo Soon-Young
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Abstract
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In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39℃, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.
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KEYWORD
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Coxsackievirus, Hand, Foot and Mouth Disease, Herpangina, Enterovirus A, Human, Risk Factors
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